3D Bioplotter Research Papers

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Displaying all papers by A. G. Patwardhan (1 results)

Osteoinductivity and biomechanical assessment of a 3D printed demineralized bone matrix-ceramic composite in a rat spine fusion model

Acta Biomaterialia 2021 Volume 127, Pages 146-158
M. A. Plantz S. Minardi J. G. Lyons A. C. Greene D. J. Ellenbogen M. Hallman J. T. Yamaguchi S. Jeong C. Yun A. E. Jakus K. R. Blank R. M. Havey M. Muriuki A. G. Patwardhan R. N. Shah W. K. Hsu S. R. Stock E. L. Hsu

We recently developed a recombinant growth factor-free bone regenerative scaffold composed of stoichiometric hydroxyapatite (HA) ceramic particles and human demineralized bone matrix (DBM) particles (HA-DBM). Here, we performed the first pre-clinical comparative evaluation of HA-DBM relative to the industry standard and established positive control, recombinant human bone morphogenetic protein-2 (rhBMP-2), using a rat posterolateral spinal fusion model (PLF). Female Sprague–Dawley rats underwent bilateral L4-L5 PLF with implantation of the HA-DBM scaffold or rhBMP-2. Fusion was evaluated using radiography and blinded manual palpation, while biomechanical testing quantified the segmental flexion-extension range-of-motion (ROM) and stiffness of the fused segments at 8-weeks postoperatively.…

PLGA Demineralized bone matrix Hydroxyapatite Hyperelastic Bone in-vivo (rat) Spinal Fusion Bone Regeneration